ParkinsonCanadaV1, Main, Exploration, bibRecord, 004096

Effect of GPi pallidotomy on motor function in Parkinson's disease

Identifieur interne : 004096 ( Main/Exploration ); précédent : 004095; suivant : 004097

Effect of GPi pallidotomy on motor function in Parkinson's disease

Auteurs : A. M. Lozano [Canada] ; A. E. Lang ; N. Galvez-Jimenez ; J. Miyasaki ; J. Duff ; W. D. Hutchinson ; J. O. Dostrovsky

Source :

Lancet : (British edition) [ 0140-6736 ] ; 1995.

RBID : Pascal:96-0025160

Descripteurs français

Pascal (Inist)
- Parkinson maladie, Effet biologique, Traitement, Chirurgie, Section, Pallidum, Motricité, Résultat, Homme.
Wicri :
- topic : Chirurgie, Homme.

English descriptors

KwdEn :
- Activities of Daily Living, Adult, Aged, Biological effect, Dyskinesia, Drug-Induced (etiology), Dyskinesia, Drug-Induced (physiopathology), Female, Follow-Up Studies, Gait (physiology), Globus Pallidus (surgery), Human, Humans, Levodopa (adverse effects), Male, Middle Aged, Motor Activity (physiology), Motricity, Pallidum, Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Parkinson Disease (surgery), Parkinson disease, Result, Section, Stereotaxic Techniques, Surgery, Treatment, Tremor (physiopathology), Videotape Recording.
MESH :
- chemical , adverse effects : Levodopa.
- drug therapy : Parkinson Disease.
- etiology : Dyskinesia, Drug-Induced.
- physiology : Gait, Motor Activity.
- physiopathology : Dyskinesia, Drug-Induced, Parkinson Disease, Tremor.
- surgery : Globus Pallidus, Parkinson Disease.
- Activities of Daily Living, Adult, Aged, Female, Follow-Up Studies, Humans, Male, Middle Aged, Stereotaxic Techniques, Videotape Recording.

Abstract

The major motor disturbances in Parkinson's disease are thought to be caused by overactivity of the internal segment of the globus pallidus (GPi), in large part due to excessive drive from the subthalamic nucleus. The excessive inhibitory activity of GPi is thought to "brake' the motor thalamus and the cortical motor system to produce the slowness, rigidity, and poverty of movement characteristic of parkinsonian states. To test the hypothesis that direct reduction of Gpi activity can improve motor function, we studied the effect of GPi pallidotomy in 14 patients. The location of the GPi nucleus was confirmed by microelectrode recording before lesion creation. Standardised videotape recordings before and after operation were randomised and scored by a "blinded' evaluator. 6 months after surgery, total motor score in the "off" state had improved by 30% and the total akinesia score by 33%. The gait score in the "off" state improved by 15% and a composite postural instability and gait score by 23%. After surgery there was almost total elimination of drug-induced involuntary movements (dyskinesias), with a 92% reduction on the side contralateral to the pallidotomy. No patient had visual or corticospinal complications. In these patients GPi pallidotomy enhanced motor performance, reduced akinesia, improved gait, and eliminated the neural elements responsible for levodopa-induced dyskinesias.

Affiliations:

Canada

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Effect of GPi pallidotomy on motor function in Parkinson's disease</title>
<author><name sortKey="Lozano, A M" sort="Lozano, A M" uniqKey="Lozano A" first="A. M." last="Lozano">A. M. Lozano</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Univ. Toronto</s1>
<s3>CAN</s3>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Univ. Toronto</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lang, A E" sort="Lang, A E" uniqKey="Lang A" first="A. E." last="Lang">A. E. Lang</name>
</author>
<author><name sortKey="Galvez Jimenez, N" sort="Galvez Jimenez, N" uniqKey="Galvez Jimenez N" first="N." last="Galvez-Jimenez">N. Galvez-Jimenez</name>
</author>
<author><name sortKey="Miyasaki, J" sort="Miyasaki, J" uniqKey="Miyasaki J" first="J." last="Miyasaki">J. Miyasaki</name>
</author>
<author><name sortKey="Duff, J" sort="Duff, J" uniqKey="Duff J" first="J." last="Duff">J. Duff</name>
</author>
<author><name sortKey="Hutchinson, W D" sort="Hutchinson, W D" uniqKey="Hutchinson W" first="W. D." last="Hutchinson">W. D. Hutchinson</name>
</author>
<author><name sortKey="Dostrovsky, J O" sort="Dostrovsky, J O" uniqKey="Dostrovsky J" first="J. O." last="Dostrovsky">J. O. Dostrovsky</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">96-0025160</idno>
<date when="1995">1995</date>
<idno type="stanalyst">PASCAL 96-0025160 INIST</idno>
<idno type="RBID">Pascal:96-0025160</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000F53</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000F70</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000E68</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000E68</idno>
<idno type="wicri:doubleKey">0140-6736:1995:Lozano A:effect:of:gpi</idno>
<idno type="wicri:Area/Main/Merge">004825</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:7475819</idno>
<idno type="wicri:Area/PubMed/Corpus">001904</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001904</idno>
<idno type="wicri:Area/PubMed/Curation">001904</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001904</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001904</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001904</idno>
<idno type="wicri:Area/Ncbi/Merge">002380</idno>
<idno type="wicri:Area/Ncbi/Curation">002380</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">002380</idno>
<idno type="wicri:doubleKey">0140-6736:1995:Lozano A:effect:of:gpi</idno>
<idno type="wicri:Area/Main/Merge">004634</idno>
<idno type="wicri:Area/Main/Curation">004096</idno>
<idno type="wicri:Area/Main/Exploration">004096</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Effect of GPi pallidotomy on motor function in Parkinson's disease</title>
<author><name sortKey="Lozano, A M" sort="Lozano, A M" uniqKey="Lozano A" first="A. M." last="Lozano">A. M. Lozano</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Univ. Toronto</s1>
<s3>CAN</s3>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Univ. Toronto</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lang, A E" sort="Lang, A E" uniqKey="Lang A" first="A. E." last="Lang">A. E. Lang</name>
</author>
<author><name sortKey="Galvez Jimenez, N" sort="Galvez Jimenez, N" uniqKey="Galvez Jimenez N" first="N." last="Galvez-Jimenez">N. Galvez-Jimenez</name>
</author>
<author><name sortKey="Miyasaki, J" sort="Miyasaki, J" uniqKey="Miyasaki J" first="J." last="Miyasaki">J. Miyasaki</name>
</author>
<author><name sortKey="Duff, J" sort="Duff, J" uniqKey="Duff J" first="J." last="Duff">J. Duff</name>
</author>
<author><name sortKey="Hutchinson, W D" sort="Hutchinson, W D" uniqKey="Hutchinson W" first="W. D." last="Hutchinson">W. D. Hutchinson</name>
</author>
<author><name sortKey="Dostrovsky, J O" sort="Dostrovsky, J O" uniqKey="Dostrovsky J" first="J. O." last="Dostrovsky">J. O. Dostrovsky</name>
</author>
</analytic>
<series><title level="j" type="main">Lancet : (British edition)</title>
<title level="j" type="abbreviated">Lancet : (Br. ed.)</title>
<idno type="ISSN">0140-6736</idno>
<imprint><date when="1995">1995</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Lancet : (British edition)</title>
<title level="j" type="abbreviated">Lancet : (Br. ed.)</title>
<idno type="ISSN">0140-6736</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Activities of Daily Living</term>
<term>Adult</term>
<term>Aged</term>
<term>Biological effect</term>
<term>Dyskinesia, Drug-Induced (etiology)</term>
<term>Dyskinesia, Drug-Induced (physiopathology)</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Gait (physiology)</term>
<term>Globus Pallidus (surgery)</term>
<term>Human</term>
<term>Humans</term>
<term>Levodopa (adverse effects)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Motor Activity (physiology)</term>
<term>Motricity</term>
<term>Pallidum</term>
<term>Parkinson Disease (drug therapy)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Parkinson Disease (surgery)</term>
<term>Parkinson disease</term>
<term>Result</term>
<term>Section</term>
<term>Stereotaxic Techniques</term>
<term>Surgery</term>
<term>Treatment</term>
<term>Tremor (physiopathology)</term>
<term>Videotape Recording</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Levodopa</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Dyskinesia, Drug-Induced</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Gait</term>
<term>Motor Activity</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Dyskinesia, Drug-Induced</term>
<term>Parkinson Disease</term>
<term>Tremor</term>
</keywords>
<keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Globus Pallidus</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Activities of Daily Living</term>
<term>Adult</term>
<term>Aged</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Stereotaxic Techniques</term>
<term>Videotape Recording</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term>
<term>Effet biologique</term>
<term>Traitement</term>
<term>Chirurgie</term>
<term>Section</term>
<term>Pallidum</term>
<term>Motricité</term>
<term>Résultat</term>
<term>Homme</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Chirurgie</term>
<term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The major motor disturbances in Parkinson's disease are thought to be caused by overactivity of the internal segment of the globus pallidus (GPi), in large part due to excessive drive from the subthalamic nucleus. The excessive inhibitory activity of GPi is thought to "brake' the motor thalamus and the cortical motor system to produce the slowness, rigidity, and poverty of movement characteristic of parkinsonian states. To test the hypothesis that direct reduction of Gpi activity can improve motor function, we studied the effect of GPi pallidotomy in 14 patients. The location of the GPi nucleus was confirmed by microelectrode recording before lesion creation. Standardised videotape recordings before and after operation were randomised and scored by a "blinded' evaluator. 6 months after surgery, total motor score in the "off" state had improved by 30% and the total akinesia score by 33%. The gait score in the "off" state improved by 15% and a composite postural instability and gait score by 23%. After surgery there was almost total elimination of drug-induced involuntary movements (dyskinesias), with a 92% reduction on the side contralateral to the pallidotomy. No patient had visual or corticospinal complications. In these patients GPi pallidotomy enhanced motor performance, reduced akinesia, improved gait, and eliminated the neural elements responsible for levodopa-induced dyskinesias.</div>
</front>
</TEI>
<affiliations><list><country><li>Canada</li>
</country>
</list>
<tree><noCountry><name sortKey="Dostrovsky, J O" sort="Dostrovsky, J O" uniqKey="Dostrovsky J" first="J. O." last="Dostrovsky">J. O. Dostrovsky</name>
<name sortKey="Duff, J" sort="Duff, J" uniqKey="Duff J" first="J." last="Duff">J. Duff</name>
<name sortKey="Galvez Jimenez, N" sort="Galvez Jimenez, N" uniqKey="Galvez Jimenez N" first="N." last="Galvez-Jimenez">N. Galvez-Jimenez</name>
<name sortKey="Hutchinson, W D" sort="Hutchinson, W D" uniqKey="Hutchinson W" first="W. D." last="Hutchinson">W. D. Hutchinson</name>
<name sortKey="Lang, A E" sort="Lang, A E" uniqKey="Lang A" first="A. E." last="Lang">A. E. Lang</name>
<name sortKey="Miyasaki, J" sort="Miyasaki, J" uniqKey="Miyasaki J" first="J." last="Miyasaki">J. Miyasaki</name>
</noCountry>
<country name="Canada"><noRegion><name sortKey="Lozano, A M" sort="Lozano, A M" uniqKey="Lozano A" first="A. M." last="Lozano">A. M. Lozano</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004096 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 004096 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Canada
   |area=    ParkinsonCanadaV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     Pascal:96-0025160
   |texte=   Effect of GPi pallidotomy on motor function in Parkinson's disease
}}

This area was generated with Dilib version V0.6.29.
Data generation: Thu May 4 22:20:19 2017. Site generation: Fri Dec 23 23:17:26 2022

La maladie de Parkinson au Canada (serveur d'exploration)

Effect of GPi pallidotomy on motor function in Parkinson's disease

Effect of GPi pallidotomy on motor function in Parkinson's disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.